Joanna Lumley.....erm, I mean Cassandra de whatever-her-name-was in Perfect Dark. Just because she was basically Joanna Lumley
Here is my top ten list and why these villains are where they are. 10.) Shinnok (from the Mortal Kombat series): A fallen Elder God, Shinnok was banished to the Nether Realm before escaping and being sent back. He is pretty crafty and *Spoiler* set up the events in the background of the Mortal Kombat reboot. 9.) Mileena: An evil clone of the Edenian Princess Kitana and a hybrid of the Tartakan race, Mileena is pure savagery. Her use of the sais is quite memorable and she is the sole reason I want to learn how to use them. 8.) Dr Robotnik/Eggman (Sonci the Hedgehog series): An iconic video game villian. This guy has done many evil and twisted stuff in the games. 7.) Quan Chi: Shinnok's right hand man, Quan Chi is very manipulative and cunning. He is also quite crafty as he has even fooled Shinnok himself by making a replica of the fallen Elder God's amulet that no one could tell the difference, not even the owner. 6.) Ghetsis (Pokemon Black/White/Black 2/White 2): Ghetsis is the most evil person in the Pokemon series. He not only brainwashed a young boy into fullfilling his own selfish needs but also and entire organization that he secretly led and many in the Unova region. Even some of his followers knew in a way what they were doing was wrong but were afraid to do anything to stop him. The entire Black and White series is the darkest of all in the entire franchise as it dealt with brainwashing, abuse, and to a lesser extent, kidnapping (although N was found by Ghetsis living alone in the woods and not really kidnapped). 5.) Bowser: Did you not expect Mario's biggest enemy not to make an appearance? Not only is Bowser an iconic villain in every sense of the word, he is also one of the most recurring villains of all time. 4.) Maleficent (Kingdom Hearts series): Not only a classic Disney villainess, Maleficent is also one of the main antagonists in the Kingdom Hearts series. Plus she is awesome as a dragon. Beating her dragon form in the first game earned her a spot on this list. 3.) Xenahort/Xenmas (Kingdom Hearts series): While essentially two different characters, I count them as one since they originally came from the same person to begin with. The biggest antagonist of the series and mastermind behind all the trouble, these two have literally stolen hearts from others and can also create minions at will. 2.) Ganon/Ganondorf: Another classic video game baddie, Ganon is just power hungry. And no matter how many times he is defeated, Ganon keeps on being resurected and retuning into power time after time. 1.) Shao Kahn: Easily the most ruthless of all video game villains, he has destroyed realms. Many in the Mortal Kombat universe despise him and even some of his followers want his power for themselves. The only truly loyal minions he has are Skarlet and Mileena. All the others have either betrayed him or left and served someone else at one point in time or another.
Cyberdemon - DooM Although the Spiderdemon was the mastermind, the Cyberdemon was the muscle. Big, scary and heavily armed with HUGE GUTS!!! The Witch - Left 4 Dead Not a boss technically, but when you hear her crying the hairs stand up on your neck
