Does boxing work against karate? Aboslutely, as long as the karateka is better at karate than the boxer is at boxing. It can also come down to the rules, if there are any. If the rules favor the boxer, then liekly the boxer will win. If the rules favor the karateka, then likely the karateka will win. I had an experience with a boxer once. We did not know each other, but a mutual friend thought we should meet and fight. Unfortunately we did. The fight was held in a boxing ring at a gym and some rules were set. By all accounts the "fight" was a draw. But I was forced to hold back. The boxer then made some smart remark about karate not really being anything at all. I had him get back in the ring and showed him what karate could be. Then he got hurt pretty bad and they both got mad at me.